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Invitrogen
Kir2.1 (KCNJ2) Polyclonal Antibody
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图: 1 / 4
Kir2.1 (KCNJ2) Antibody (PA5-72498) in IHC (P)
Immunohistochemistry analysis of Kir2.1 (KCNJ2) in formalin-fixed and paraffin-embedded human lung carcinoma. Samples were incubated with Kir2.1 (KCNJ2) polyclonal antibody (Product # PA5-72498) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-72498
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 401-427 amino acids from the C-terminal region of human KCNJ2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.28 mg/mL
规格
112 µg
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The KIR2 subunit family includes 2. 1, 2. 2, 2. 3 and 2. 4. Unlike G protein-coupled KIR3 subunits, KIR2. 1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. KIR2. 1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, KIR2. 1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2. 1 colocalizes with KIR5. 1 in the proximal tubule. KIR2. 1, 2. 2 and 2. 3 associate with the membrane-associated guanylate kinase synapseassociated protein 97 in the cerebellum and heart. Phosphorylation of KIR2. 2 by protein kinase A inhibits the associates with SAP97.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cardiac inward rectifier potassium channel; HHIRK 1; HIRK 1; Inward rectifier K; Inward rectifier K(+) channel Kir2.1; Inward rectifier potassium channel 2; IRK 1; IRK-1; IRK2; LQT 7; Potassium channel, inwardly rectifying subfamily J member 2; SQT 3
基因别名: IRK1; Kcnf1; KCNJ2; Kir2.1
UniProt ID: (Mouse) P35561
Entrez Gene ID: (Mouse) 16518
regulation of heart rate
transport
ion transport
potassium ion transport
potassium ion import
regulation of skeletal muscle contraction via regulation of action potential
magnesium ion transport
regulation of ion transmembrane transport
protein homotetramerization
relaxation of cardiac muscle
regulation of membrane repolarization
potassium ion transmembrane transport
cardiac muscle cell action potential
cardiac muscle cell action potential involved in contraction
regulation of cardiac muscle cell contraction
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
relaxation of skeletal muscle
positive regulation of potassium ion transmembrane transport
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