Antibodies Inc

Kv7.1/KCNQ1 K+ Channel Monoclonal Antibody (N37A/10), FL490

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说明书
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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
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Kv7.1/KCNQ1 K+ Channel Monoclonal Antibody (N37A/10), FL490

产品信息

75-081-FL490

应用
建议稀释比
已发表文章

免疫组化（冰冻） (IHC (F))

Assay-dependent
-

免疫细胞化学 (ICC/IF)

Assay-dependent
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Hamster, Human, Mouse, Rabbit, Rat, Xenopus

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

N37A/10

抗原

Fusion protein amino acids 2-101 of human KCNQ1(accession number P51787) produced recombinantly in E. Coli.
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偶联物

FL490 FL490 FL490

激发/发射光谱

491/515 nm

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Dry ice (international)

产品详细信息

For maximum recovery of product, centrifuge the vial prior to removing the cap.

靶标信息

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an alpha subunit KCNQ1 and a beta subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; kidney and cardiac voltage dependend K+ channel; KQT-like 1; KvLQT1 voltage-gated delayed rectifier potassium channel; potassium channel, voltage gated KQT-like subfamily Q, member 1; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; potassium voltage-gated channel, subfamily Q, member 1; slow delayed rectifier channel subunit; Voltage-gated potassium channel subunit Kv7.1

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基因别名: ATFB1; ATFB3; AW559127; I79_015904; JLNS1; KCNA8; KCNA9; KCNQ1; kqt-3; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS

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UniProt ID: (Human) P51787, (Mouse) P97414, (Rat) Q9Z0N7

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Entrez Gene ID: (Human) 3784, (Rabbit) 100009443, (Mouse) 16535, (Chinese hamster) 100761481, (Rat) 84020

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功能
voltage-gated potassium channel activity delayed rectifier potassium channel activity protein binding calmodulin binding phosphatidylinositol-4,5-bisphosphate binding protein phosphatase 1 binding outward rectifier potassium channel activity protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding ion channel binding voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization scaffold protein binding voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization ion channel activity voltage-gated ion channel activity potassium channel activity protein homodimerization activity voltage-gated ion channel
参与通路
positive regulation of defense response to virus by host regulation of gene expression by genetic imprinting sensory perception of sound regulation of heart contraction positive regulation of heart rate gene silencing cellular response to drug inner ear development intestinal absorption cardiac muscle contraction regulation of membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization positive regulation of cardiac muscle contraction regulation of gastric acid secretion cardiac conduction renal absorption cellular response to cAMP potassium ion export potassium ion transmembrane transport cellular response to epinephrine stimulus cardiovascular system development ventricular cardiac muscle cell action potential membrane repolarization during action potential membrane repolarization during cardiac muscle cell action potential atrial cardiac muscle cell action potential regulation of heart rate by cardiac conduction potassium ion export across plasma membrane xenophagy membrane repolarization during ventricular cardiac muscle cell action potential positive regulation of potassium ion transmembrane transport transport ion transport potassium ion transport regulation of ion transmembrane transport regulation of membrane potential negative regulation of insulin secretion transmembrane transport positive regulation of gastric acid secretion response to anesthetic male gonad development
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