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Abnova
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Sequence of this protein is as follows: PEEYEGHHVM EPPVITEQSP RRLVVFPTDD ISLKCEASGK PEVQFRWTRD GVHFKPKEEL GVTVYQSPHS GSFTITGNNS NFAQRFQGIY RCFASNKLGT AMSHEIRLMA
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
仅用于科研。不用于诊断过程。未经明确授权不得转售。