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Invitrogen
L3MBTL1 Polyclonal Antibody
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L3MBTL1 Antibody (PA5-115488) in IHC (P)
Immunohistochemistry analysis of L3MBTL1 in rat pancreatic tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115488) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115488
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human L3MBTL1(Accession Q9Y468), corresponding to amino acid residues D452-S502.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total L3MBTL1.
靶标信息
L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: H-l(3)mbt; H-l(3)mbt protein; L(3)mbt protein homolog; l(3)mbt-like 1; l(3)mbt-like 1 (Drosophila); L3MBTL1; L3MBTL1, histone methyl-lysine binding protein; lethal (3) malignant brain tumor l(3); Lethal(3)malignant brain tumor-like protein 1; RP1-138B7.1; unnamed protein product
基因别名: C630004G01; dJ138B7.3; H-L(3)MBT; KIAA0681; L3MBT; L3MBTL; L3MBTL1; mKIAA0681; RGD1307316; ZC2HC3
UniProt ID: (Human) Q9Y468, (Mouse) A2A5N8, (Rat) D3ZWK4
Entrez Gene ID: (Human) 26013, (Mouse) 241764, (Rat) 311613
chromatin binding
protein binding
zinc ion binding
nucleosome binding
SAM domain binding
histone binding
identical protein binding
metal ion binding
histone H4K20me2 reader activity
histone H1 reader activity
transcription factor activity, sequence-specific DNA binding
nucleosomal histone binding
methylated histone binding
molecular_function
chromatin/chromatin-binding, or -regulatory protein
chromatin organization
regulation of transcription, DNA-templated
regulation of mitotic nuclear division
hemopoiesis
heterochromatin assembly
regulation of megakaryocyte differentiation
negative regulation of transcription, DNA-templated
regulation of cell cycle
regulation of macromolecule metabolic process
regulation of primary metabolic process
constitutive heterochromatin formation
transcription, DNA-templated
chromatin modification
regulation of gene expression, epigenetic
biological_process
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