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Invitrogen
L3MBTL2 Monoclonal Antibody (4F4)
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产品信息
MA5-22704
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
4F4
抗原
L3MBTL2 (NP_113676, 642 a.a. ~ 705 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Peptide Sequence: RQGSKKPLLE DDPQGARKIS SEPVPGEIIA VRVKEEHLDV ASPDKASSPE LPVSVENIKQ ETDD
靶标信息
The L3MBTL2 gene encodes a protein that belongs to the MBT (malignant brain tumor) family, which is characterized by the presence of MBT domains. These proteins are known for their role in chromatin organization and transcriptional repression. L3MBTL2 specifically acts as a transcriptional repressor, capable of compacting chromatin independent of histone modifications, thereby facilitating gene silencing. Its repressive activity is associated with the suppression of specific target genes, such as CGA in pancreatic cells, indicating its potential role in regulating cellular differentiation and proliferation. The MBT domains in L3MBTL2 are methyl-lysine readers that further contribute to its role in modulating chromatin state, impacting stem cell maintenance and developmental processes. Understanding L3MBTL2's functions and interactions is crucial due to its involvement in maintaining genomic integrity and its implications in cancer biology, particularly in chromatin-mediated gene regulation mechanisms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: H-l(3)mbt-like protein 2; l(3)mbt-like 2; L(3)mbt-like protein 2; Lethal(3)malignant brain tumor-like protein 2; lmbt-like 2 (Drosophila) isoform 1; lmbt-like 2 (Drosophila) isoform 2
基因别名: H-l(3)mbt-l; L3MBT; L3MBTL2
UniProt ID: (Human) Q969R5
Entrez Gene ID: (Human) 83746
