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Abnova
LAIR1 Polyclonal Antibody, MaxPab™
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LAIR1 Antibody (H00003903-D01P) in WB
Western Blot analysis of LAIR1 expression in transfected 293T cell line (H00003903-T01) by LAIR1 MaxPab polyclonal antibody.
Lane 1: LAIR1 transfected lysate(31.68 KDa).
Lane 2: Non-transfected lysate.
Lane 1: LAIR1 transfected lysate(31.68 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00003903-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
LAIR1 (AAH27899, 1 a.a. approximately 287 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MSPHPTALLG LVLCLAQTIH TQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPS ESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSGGPDSP DTEPGSSAGP TQRPSDNSHN EHAPASQGLK AEHLYILIGV SVVFLFCLLL LVLFCLHRQN QIKQGPPRSK DEEQKPQQRP DLAVDVLERT ADKATVNGLP EKDRETDTSA LAAGSSQEVT YAQLDHWALT QRTARAVSPQ STKPMAESIT YAAVARH
靶标信息
CD305, also known as LAIR1, is a type I transmembrane glycoprotein with an extracellular Ig-like domain and two intracellular ITIMs. It is expressed on a wide range of immune cells, including T, NK, and B cells, monocytes, dendritic cells, eosinophils, basophils, and mast cells. In humans, CD305 is also present on CD34+ hematopoietic progenitor cells and thymocytes. Several isoforms exist due to alternative splicing, with expression varying between cell types. CD305 functions as an inhibitory receptor, playing a key role in regulating immune responses. It blocks cytokine-mediated signaling, cell proliferation, and apoptosis. In NK, B, and T cells, CD305 modulates cytolytic functions and cytokine production, down-regulating IL2 and IFNG in CD4+ T cells while inducing transforming growth factor beta. In B cells, it reduces IgG and IgE production and decreases IL8, IL10, and TNF secretion. Activation of CD305 through tyrosine phosphorylation recruits phosphatases PTPN6 and PTPN11, although it may also function independently of SH2-containing phosphatases. It inhibits differentiation of peripheral blood precursors into dendritic cells and has been shown to induce apoptosis in myeloid leukemia cell lines. Collagens are identified as ligands for CD305, underscoring its role in immune regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD305; immunoglobulin heavy chain variable region; LAIR-1; leukocyte-associated Ig-like receptor 1; Leukocyte-associated immunoglobulin-like receptor 1
基因别名: 5133400O11Rik; BB115266; CD305; D7Bwg0421e; LAIR-1; LAIR1
UniProt ID: (Human) Q6GTX8, (Mouse) Q8BG84
Entrez Gene ID: (Human) 3903, (Mouse) 52855
