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Bethyl Laboratories
LAX Polyclonal Antibody
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LAX Antibody (A304-459A) in WB
Detection of human LAX by western blot. Samples: Whole cell lysate (50 µg) prepared using RIPA buffer from HeLa, HEK293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-LAX antibody (Product # A304-459A) (lot A304-459A-1) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A304-459A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 348 to 398 of human Lymphocyte Transmembrane Adaptor 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Lymphocyte activation gene 1 (LAX1) is located on chromosome 2p16.1 and encodes an immunoregulatory protein that is expressed primarily on lymphocytes, including T cells, B cells, and other immune cells. LAX1 functions as a negative regulator of lymphocyte activation and signaling, playing a crucial role in maintaining immune homeostasis by attenuating excessive immune responses. It acts by modulating signaling pathways that are initiated through surface receptors on lymphocytes, thereby influencing lymphocyte proliferation, cytokine production, and cellular responses during immune activation. Dysregulation of LAX1 expression or function can lead to autoimmune diseases due to impaired control of immune activation. Research into LAX1 focuses on its potential for therapeutic modulation in autoimmune disorders and its role in balancing immune responses, which is essential for maintaining health and preventing pathogenic immune conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LAT-like membrane associated protein; Linker for activation of X cells; Lymphocyte transmembrane adapter 1; Membrane-associated adapter protein LAX
Gene Aliases: LAX; LAX1
UniProt ID: (Human) Q8IWV1
Entrez Gene ID: (Human) 54900
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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