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Invitrogen
LDLR Recombinant Rabbit Monoclonal Antibody (1A7)
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LDLR Antibody (MA571888) in IHC (P)
Immunohistochemistry analysis of LDLR on paraffin-embedded Mouse Adrenal Gland tissue. Antigen retrieval by boiling in sodium citrate buffer (pH 6.0) for 15 min. Samples were incubated with LDLR Recombinant Monoclonal (Product # MA571888) using a dilution at 1:400 overnight at 4°C. Followed by DAB staining.
产品信息
MA571888
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1A7
抗原
A synthesized peptide derived from human LDL receptor.
偶联物
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LDL receptor; ldl-r; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3; unnamed protein product
基因别名: FH; FHC; FHCL1; Hlb301; LDLCQ2; LDLR
UniProt ID: (Human) P01130, (Mouse) P35951
Entrez Gene ID: (Human) 3949, (Mouse) 16835
beta-amyloid binding
virus receptor activity
protease binding
low-density lipoprotein receptor activity
calcium ion binding
protein binding
low-density lipoprotein particle binding
very-low-density lipoprotein particle receptor activity
clathrin heavy chain binding
identical protein binding
binding, bridging
lipoprotein particle binding
glycoprotein binding
apolipoprotein
retinoid metabolic process
negative regulation of receptor recycling
lipid metabolic process
lipid transport
endocytosis
receptor-mediated endocytosis
phagocytosis
long-term memory
steroid metabolic process
cholesterol metabolic process
negative regulation of macromolecule metabolic process
positive regulation of gene expression
negative regulation of gene expression
positive regulation of triglyceride biosynthetic process
regulation of phosphatidylcholine catabolic process
negative regulation of low-density lipoprotein particle clearance
phospholipid transport
intestinal cholesterol absorption
cholesterol transport
plasma lipoprotein particle clearance
low-density lipoprotein particle clearance
high-density lipoprotein particle clearance
lipoprotein metabolic process
lipoprotein catabolic process
cholesterol homeostasis
viral entry into host cell
artery morphogenesis
positive regulation of inflammatory response
negative regulation of multicellular organismal process
regulation of protein metabolic process
negative regulation of protein metabolic process
establishment of localization in cell
artery development
response to caloric restriction
negative regulation of astrocyte activation
cholesterol import
cellular response to fatty acid
cellular response to low-density lipoprotein particle stimulus
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
regulation of cholesterol metabolic process
beta-amyloid clearance
amyloid-beta clearance by cellular catabolic process
negative regulation of microglial cell activation
positive regulation of lysosomal protein catabolic process
negative regulation of amyloid fibril formation
transport
regulation of cholesterol homeostasis
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