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Invitrogen
LDLRAP1 Monoclonal Antibody (OTI4B10)
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LDLRAP1 Antibody (MA5-25755) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded carcinoma of human liver tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a LDLRAP1 monoclonal antibody (Product # MA5-25755).
产品信息
MA5-25755
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI4B10
抗原
Full length human recombinant protein of LDLRAP1 produced in HEK293T cell
偶联物
形式
Liquid
浓度
0.62 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Autosomal recessive hypercholesterolemia protein; DKFZp586D0624; LDL receptor adaptor protein; Low density lipoprotein receptor adapter protein 1; MGC34705; RP11-70P17.2
基因别名: ARH; ARH1; ARH2; FHCB1; FHCB2; LDLRAP1
UniProt ID: (Human) Q5SW96
Entrez Gene ID: (Human) 26119
beta-amyloid binding
phosphotyrosine binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
receptor signaling complex scaffold activity
clathrin binding
signaling adaptor activity
AP-2 adaptor complex binding
clathrin adaptor activity
low-density lipoprotein particle receptor binding
scaffold/adaptor protein
transport
receptor-mediated endocytosis
cholesterol metabolic process
positive regulation of signal transduction
receptor internalization
cholesterol homeostasis
amyloid precursor protein metabolic process
regulation of protein binding
positive regulation of receptor-mediated endocytosis
regulation of establishment of protein localization to plasma membrane
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
positive regulation of cholesterol metabolic process
