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Invitrogen
LEF1 (Alternate Exon) Monoclonal Antibody (1C3)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA1-12487
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1C3
抗原
Recombinant full-length LEF-1 protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
规格
100 µg
纯化类型
Protein A/G
保存液
PBS
内含物
0.08% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; MIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp586H0919; FLJ46390; HGNC:6551; hLEF-1 isoform; hLEF-1(8A); HMG Binding Domain; HMG box transcription factor; OTTHUMP00000219736; OTTHUMP00000219737; T cell-specific transcription factor 1-alpha; TCF1-alpha; unnamed protein product
基因别名: ECTD1; ECTD17; LEF-1; TCF10; TCF1ALPHA; TCF7L3
UniProt ID: (Human) Q9UJU2
Entrez Gene ID: (Human) 51176
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription corepressor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
DNA binding, bending
estrogen receptor binding
histone deacetylase binding
sequence-specific DNA binding
gamma-catenin binding
armadillo repeat domain binding
C2H2 zinc finger domain binding
transcription regulator inhibitor activity
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
epithelial to mesenchymal transition
regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
Wnt signaling pathway
cell differentiation
neutrophil differentiation
positive regulation of cell migration
positive regulation of granulocyte differentiation
negative regulation of interleukin-13 production
negative regulation of interleukin-4 production
negative regulation of interleukin-5 production
negative regulation of apoptotic process
negative regulation of DNA binding
positive regulation by host of viral transcription
T-helper 1 cell differentiation
positive regulation of gamma-delta T cell differentiation
positive regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
canonical Wnt signaling pathway
cell chemotaxis
secondary palate development
protein localization to chromatin
cellular response to cytokine stimulus
cellular response to interleukin-4
positive regulation of cell proliferation in bone marrow
negative regulation of apoptotic process in bone marrow
positive regulation of cell cycle process
positive regulation of odontoblast differentiation
positive regulation of endothelial cell-matrix adhesion via fibronectin
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