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NeoBiotechnologies
LEF1/TCF1 alpha (Transcription Factor) Recombinant Rabbit Monoclonal Antibody (LEF1/422R)
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LEF1/TCF1 alpha (Transcription Factor) Antibody (51176-RBM2-P0) in IHC (P)
Formalin-fixed, paraffin-embedded analysis of human lymph node. Nuclear staining of non-germinal center cells using LEF1/422R at 2 µg/mL in PBS for 30 min RT. HIER: Tris/EDTA, pH9.0, 45 min. 2 °: HRP-polymer, 30 min. DAB, 5 min.
产品信息
51176-RBM2-P0
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
LEF1/422R
抗原
Recombinant fragment (around aa100-200) of human LEF1 protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp586H0919; FLJ46390; HGNC:6551; HMG Binding Domain; LEF-1; Lymphoid enhancer-binding factor 1; OTTHUMP00000219736; OTTHUMP00000219737; T cell-specific transcription factor 1-alpha; TCF1-alpha
基因别名: LEF-1; LEF1; TCF10; TCF1ALPHA; TCF7L3
UniProt ID: (Human) Q9UJU2
Entrez Gene ID: (Human) 51176
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
beta-catenin binding
transcription factor binding
DNA binding, bending
estrogen receptor activity
estrogen receptor binding
enhancer binding
histone binding
histone deacetylase binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
sequence-specific DNA binding
transcription regulatory region DNA binding
gamma-catenin binding
armadillo repeat domain binding
C2H2 zinc finger domain binding
DNA-binding transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
patterning of blood vessels
osteoblast differentiation
neural crest cell migration
somitogenesis
kidney development
epithelial to mesenchymal transition
sprouting angiogenesis
transcription from RNA polymerase II promoter
Wnt signaling pathway, calcium modulating pathway
positive regulation of cell proliferation
response to lithium ion
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
Wnt signaling pathway
regulation of striated muscle tissue development
dentate gyrus development
hypothalamus development
forebrain radial glial cell differentiation
forebrain neuroblast division
forebrain neuron differentiation
formation of radial glial scaffolds
regulation of cell-cell adhesion
neutrophil differentiation
positive regulation of cell growth
embryonic limb morphogenesis
positive regulation of cell migration
BMP signaling pathway
positive regulation of granulocyte differentiation
mammary gland development
organ regeneration
negative regulation of interleukin-13 production
negative regulation of interleukin-4 production
negative regulation of interleukin-5 production
T cell receptor V(D)J recombination
B cell proliferation
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of DNA binding
steroid hormone mediated signaling pathway
tongue development
skin development
positive regulation by host of viral transcription
histone H3 acetylation
histone H4 acetylation
T-helper 1 cell differentiation
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
alpha-beta T cell differentiation
eye pigmentation
paraxial mesoderm formation
muscle fiber development
sensory perception of taste
palate development
anatomical structure regression
canonical Wnt signaling pathway
face morphogenesis
cell chemotaxis
apoptotic process involved in morphogenesis
chorio-allantoic fusion
trachea gland development
cellular response to cytokine stimulus
cellular response to interleukin-4
positive regulation of cell proliferation in bone marrow
negative regulation of apoptotic process in bone marrow
odontoblast differentiation
negative regulation of estrogen receptor binding
negative regulation of canonical Wnt signaling pathway
apoptotic process involved in patterning of blood vessels
beta-catenin-TCF complex assembly
