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Invitrogen
LGR5 Monoclonal Antibody (2G11)
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LGR5 Antibody (MA5-32978) in WB
Western blot analysis of LGR5 in Lane 1: Hct116 whole cell lysate (40 µg), Lane 2: SGC7901 whole cell lysate (40 µg), Lane 3: HeLa whole cell lysate (40 µg), Lane 4: PC12 whole cell lysate (40 µg), Lane 5: CT-26 whole cell lysate (40 µg). Sample was incubated with LGR5 monoclonal antibody (Product # MA5-32978) using a 1:500 dilution.
产品信息
MA5-32978
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
2G11
抗原
Recombinant LGR5 protein, corresponding to amino acids 23-317 of Human LGR5.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
G protein-coupled receptor GPR49 has been reported to be expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries and from human germ cell, uterus, and brain libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: follicle expressed hormone; G protein-coupled receptor 49; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; leucine-rich repeat containing G protein-coupled receptor 5; leucine-rich repeat-containing G protein-coupled receptor 5; Leucine-rich repeat-containing G-protein coupled receptor 5; orphan G protein-coupled receptor HG38; Orphan G-protein coupled receptor FEX
基因别名: FEX; GPR49; GPR67; GRP49; HG38; LGR5
UniProt ID: (Human) O75473, (Mouse) Q9Z1P4, (Rat) D4AC13
Entrez Gene ID: (Human) 8549, (Mouse) 14160, (Rat) 299802
hair follicle development
G-protein coupled receptor signaling pathway
oocyte differentiation
regulation of cell proliferation
inner ear development
positive regulation of canonical Wnt signaling pathway
epithelial cell proliferation involved in renal tubule morphogenesis
signal transduction
biological_process
