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Invitrogen
LIF Polyclonal Antibody
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LIF Antibody (PA5-85116) in WB
Western Blot using LIF Polyclonal Antibody (Product # PA5-85116). Various whole cell extracts (30 µg) were separated by 12% SDS-PAGE, and the membrane was blotted with LIF Polyclonal Antibody (Product # PA5-85116) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-85116
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human LIF. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.07 mg/mL
规格
107 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Dog (91%), Pig (87%), Rabbit (90%), Bovine (88%).
Positive Control: 293T, A431, HeLa, HepG2, HUVEC.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: D factor; Differentiation-stimulating factor; Leukemia inhibitory factor; LIF; Melanoma-derived LPL inhibitor; MLPLI
基因别名: HILDA; LIF
Entrez Gene ID: (Human) 3976
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