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Bethyl Laboratories

LIS-1 Polyclonal Antibody

View all (14) LIS1 antibodies

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Additional Information:

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LIS-1 Polyclonal Antibody

Product Details

A300-409A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 1 and 50 of human Lissencephaly 1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

tris citrate/phosphate, pH 7-8

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Zebrafish, X. laevis, X. tropicalis, Chicken, Bovine, Pig, Cat, Orangutan and Chimpanzee

Target Information

VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: homolog of Miller-Dieker gene; LIS-1; lissencephaly 1 protein; lissencephaly-1 protein; MGC25297; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAF-AH beta; PAFAH alpha; Pafaha/Lis1; PHFAH1B1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); platelet-activating factor acetylhydrolase 45kD subunit; platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta); platelet-activating factor acetylhydrolase IB subunit alpha; RP23-194P5.2; unnamed protein product

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Gene Aliases: LIS-1; LIS1; LIS2; MDCR; MDS; Mdsh; MMS10-U; Ms10u; NudF; PAFAH; Pafaha

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UniProt ID: (Human) P43034, (Rat) P63004, (Mouse) P63005

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Entrez Gene ID: (Human) 5048, (Rat) 83572, (Mouse) 18472

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Function(s)
protein binding microtubule binding heparin binding dynactin binding identical protein binding phospholipase binding macromolecular complex binding dynein intermediate chain binding protein heterodimerization activity phosphoprotein binding dynein complex binding platelet-activating factor acetyltransferase activity
Process(es)
establishment of mitotic spindle orientation microtubule cytoskeleton organization acrosome assembly neuron migration microtubule-based process nuclear migration chemical synaptic transmission nervous system development neuroblast proliferation learning or memory retrograde axonal transport adult locomotory behavior negative regulation of neuron projection development stem cell division transmission of nerve impulse corpus callosum morphogenesis hippocampus development layer formation in cerebral cortex cerebral cortex neuron differentiation cerebral cortex development actin cytoskeleton organization forebrain development microtubule organizing center organization reelin-mediated signaling pathway positive regulation of embryonic development establishment of planar polarity of embryonic epithelium cortical microtubule organization positive regulation of axon extension positive regulation of mitotic cell cycle platelet activating factor metabolic process vesicle transport along microtubule brain morphogenesis modulation of synaptic transmission neuromuscular process controlling balance microtubule sliding positive regulation of cellular component organization establishment of organelle localization establishment of centrosome localization auditory receptor cell development positive regulation of dendritic spine morphogenesis platelet activating factor catabolic process regulation of microtubule cytoskeleton organization cochlea development microtubule cytoskeleton organization involved in establishment of planar polarity regulation of postsynapse organization ameboidal-type cell migration positive regulation of cytokine-mediated signaling pathway protein secretion cell migration osteoclast development negative regulation of JNK cascade nuclear envelope disassembly centrosome localization maintenance of centrosome location
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