Invitrogen

LKB1 Monoclonal Antibody (206R24)

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1 篇参考文献
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说明书
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说明书
实验方案
问题与答案
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说明书
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问题与答案
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产品信息

AHO1392

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:10-1:50
-

免疫细胞化学 (ICC/IF)

1:250
-
产品规格

种属反应

Human, Mouse, Non-human primate, Rat

已发表种属

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

206R24

抗原

Recombinant fragment of human LKB1 expressed in E. coli.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

purified

保存液

PBS, pH 7.2, with 1% BSA

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2536337

靶标信息

LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CAMK group; CAMKL family; Liver kinase B1; Liver kinase B1 homolog; LKB 1; LKB-1; LKB1; LKB1(S); polarization-related protein LKB1; Renal carcinoma antigen NY-REN-19; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase STK11

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基因别名: AA408040; hLKB1; LKB1; Par-4; PJS; R75140; STK11

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UniProt ID: (Human) Q15831, (Rat) D4AE59, (Mouse) Q9WTK7

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Entrez Gene ID: (Human) 6794, (Rat) 314621, (Mouse) 20869

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功能
magnesium ion binding p53 binding protein serine/threonine kinase activity protein binding ATP binding LRR domain binding protein kinase activator activity protein complex binding
参与通路
regulation of cell growth tissue homeostasis vasculature development protein phosphorylation autophagy cellular response to DNA damage stimulus cell cycle arrest spermatid development axonogenesis negative regulation of cell proliferation response to ionizing radiation establishment of cell polarity regulation of Wnt signaling pathway negative regulation of cell growth positive regulation of transforming growth factor beta receptor signaling pathway activation of protein kinase activity response to glucagon response to lipid TCR signalosome assembly glucose homeostasis anoikis response to peptide hormone positive thymic T cell selection positive regulation of gluconeogenesis positive regulation of protein kinase activity protein autophosphorylation regulation of dendrite morphogenesis positive regulation of peptidyl-tyrosine phosphorylation positive regulation of axonogenesis T cell receptor signaling pathway protein heterooligomerization Golgi localization regulation of protein kinase B signaling canonical Wnt signaling pathway negative regulation of epithelial cell proliferation involved in prostate gland development cellular response to UV-B intrinsic apoptotic signaling pathway by p53 class mediator dendrite extension positive regulation of protein localization to nucleus positive regulation of autophagy negative regulation of lipid biosynthetic process positive regulation of protein serine/threonine kinase activity regulation of signal transduction by p53 class mediator negative regulation of TORC1 signaling
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