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LL-37 Polyclonal Antibody
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LL-37 Antibody (OSC00028G-500UG) in ICC/IF
Staining of a cytospin preparation of peripheral blood mononuclear cells isolated from buffycoat. Cells were left to air dry and then fixed with cold acetone (90 seconds) and blocked with PBS containing 1% FCS and 0.1% saponin (blocking buffer) for 20 minutes. Cells were then washed twice in PBS and incubated with Rabbit antibody to LL-37 (OSC00028G), diluted 50 µg/mL: in blocking buffer, for 1 hour at room temperature. Cells were washed twice in PBS followed by incubation for 30 minutes with the FITC-labeled secondary antibody. Finally, c... View More
产品信息
OSC00028G-500UG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from human Cathelicidin antimicrobial peptide conjugated to an immunogenic carrier protein has been used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
规格
500 µg
纯化类型
Ammonium sulfate precipitation
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Cathelicidin antimicrobial peptide.
靶标信息
LL-37 is a cationic antimicrobial peptide derived from the precursor protein hCAP18, which is encoded by the CAMP gene. It is produced by epithelial cells and immune cells such as neutrophils and plays an important role in innate immunity. LL-37 exhibits broad antimicrobial activity against bacteria, viruses, and fungi, and also functions as an immunomodulatory molecule by influencing inflammation, chemotaxis, and wound healing. In addition to host defense, dysregulated LL-37 expression has been associated with inflammatory diseases and certain cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 18 kDa cationic antimicrobial protein; CAMP; CAP-18; Cathelicidin antimicrobial peptide; epididymis secretory sperm binding protein
基因别名: CAMP; CAP-18; CAP18; CRAMP; FALL-39; FALL39; HSD26; LL37
UniProt ID: (Human) P49913
Entrez Gene ID: (Human) 820
response to yeast
innate immune response in mucosa
immune system process
prostaglandin production involved in inflammatory response
chronic inflammatory response
positive regulation of antimicrobial humoral response
defense response
positive regulation of cell proliferation
response to glucose
leukotriene biosynthetic process
antibacterial humoral response
antifungal humoral response
cytolysis
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of insulin secretion involved in cellular response to glucose stimulus
modification of morphology or physiology of other organism
neutrophil activation
defense response to bacterium
negative regulation of apoptotic process
innate immune response
positive regulation of angiogenesis
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
cytolysis by host of symbiont cells
killing by host of symbiont cells
antimicrobial humoral immune response mediated by antimicrobial peptide
cellular response to lipopolysaccharide
cellular response to peptidoglycan
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to exogenous dsRNA
positive regulation of monocyte chemotactic protein-1 production
positive regulation of macrophage inflammatory protein 1 alpha production
dentinogenesis
cellular response to butyrate
amyloid fibril formation
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