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Abnova
LNX1 Monoclonal Antibody (4E3)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00084708-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4E3
抗原
LNX1 (NP_116011, 19 a.a. approximately 118 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: DNVGNLHFLY SELCKGAFHY GLTKDRKRRS QDGCPDGCAS LTATAPSPEV SAAATISLMT DEPGLDNPAY VSSAEDGQPA ISPVDSGRSN RTRARPFERS
靶标信息
Lnx1 (Ligand of Numb Protein X 1) protein is encoded by the Lnx1 gene located on chromosome 4 in humans and is known as PDZRN2 (PDZ domain-containing RING finger 2). It is through its RING finger and PDZ domains that Lnx1 forms oligomers and interacts with some of its target proteins such as JAM4 to form multiprotein complexes. Lnx1 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Phosphotyrosine binding domain (PTB) on Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus positively regulates the Notch signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ligand of numb-protein X 1, E3 ubiquitin protein ligase; MPDZ; multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX; numb-binding protein 1; PDZ domain-containing ring finger protein 2; RING-type E3 ubiquitin transferase LNX; unnamed protein product
基因别名: LNX; MPDZ; PDZRN2
UniProt ID: (Human) Q8TBB1
Entrez Gene ID: (Human) 84708
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