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Invitrogen
LNX2 Polyclonal Antibody
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LNX2 Antibody (PA5-95818) in WB
Western blot analysis of LNX2 in extracts of various cell lines. Samples were incubated with LNX2 Polyclonal antibody (Product # PA5-95818) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
产品信息
PA5-95818
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human LNX2 (NP_6992021)
偶联物
形式
Liquid
浓度
1.72 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MGTTSDEMVS VEQTSSSSLN PLCFECGQQH WTRENHLYNY QNEVDDDLVC HICLQPLLQP LDTPCGHTFC YKCLRNFLQE KDFCPLDRKR LHFKLCKKSS ILVHKLLDKL LVLCPFSSVC KDVMQRCDLE AHLKNRCPGA SHRRVALERR KTSRTQAEIE NENGPTLLDP AGTLSPEADC LGTGAVPVER HLTSASLSTW SEEPGLDNPA FEESAGADTT QQPLSLPEGE ITTIEIHRSN; Positive Samples: A-375, A-549, Rat thymus
靶标信息
LNX2 (Ligand of Numb Protein X 2) protein is encoded by the LNX2 gene located on chromosome 13 in humans and is known as PDZRN1 (PDZ domain-containing RING finger 1). It is through its PDZ domains that LNX2 forms oligomers and interacts with some of its target proteins. LNX2 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus modulates the Notch signaling pathway.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ligand of Numb protein X 2; Numb-binding protein 2; PDZ domain containing ring finger 1; PDZ domain-containing RING finger protein 1
基因别名: 9630046H24; AW209022; LNX2; PDZRN1
UniProt ID: (Human) Q8N448, (Mouse) Q91XL2
Entrez Gene ID: (Human) 222484, (Mouse) 140887, (Rat) 360761
