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Alomone Labs, LTD
LPAR1 (EDG2) (extracellular) Polyclonal Antibody
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LPAR1 (EDG2) (extracellular) Antibody (ALR-031-200UL) in WB
Western blot analysis of rat brain membrane (lanes 1 and 3), mouse brain membrane (lanes 2 and 4) and human brain glioblastoma U87 MG cell line (lanes 5 and 6) lysate: - 1,2,5. Anti-LPAR1 (EDG2) (extracellular) Antibody (#ALR-031), (1:400).3,4,6. Anti-LPAR1 (EDG2) (extracellular) Antibody , preincubated with LPAR1/EDG2 (extracellular) Blocking Peptide (#BLP-LR031).
产品信息
ALR-031-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)RSGKYLATEWNTVSK, corresponding to amino acid residues 36-50 of rat LPA1 receptor, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; G-protein coupled receptor 26; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor 1; Lysophosphatidic acid receptor Edg-2; Rec1.3; ventricular zone gene 1; VZG-1
基因别名: AI326300; edg-2; EDG2; Gpcr26; Gpcr91; GPR26; Kdt2; LPA1; LPAR1; Mrec1.3; rec.1.3; vzg-1; VZG1
UniProt ID: (Human) Q92633, (Rat) P56487, (Mouse) P61793
Entrez Gene ID: (Human) 1902, (Rat) 116744, (Mouse) 14745
activation of MAPK activity
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
regulation of cell shape
negative regulation of neuron projection development
oligodendrocyte development
cerebellum development
optic nerve development
corpus callosum development
negative regulation of cAMP biosynthetic process
bleb assembly
positive regulation of Rho protein signal transduction
myelination
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of stress fiber assembly
cell chemotaxis
positive regulation of dendritic spine development
cellular response to oxygen levels
positive regulation of smooth muscle cell chemotaxis
cellular response to 1-oleoyl-sn-glycerol 3-phosphate
positive regulation of cell death
neurogenesis
signal transduction
