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Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey (100%) Gorilla, Marmoset, Mouse (94%) Rat, Dog, Panda (88%).
The Latrophilin family of G protein-coupled receptors consists of three members, latrophilin-1, 2 and 3, each of which displays distinct tissue distribution and function. Latrophilin-1, the most characterized member of this family, acts as a receptor for a-latrotoxin, a component of venom from the black widow spider. Binding of a-latrotoxin to latrophilin-1 triggers synaptic vesicle exocytosis via both Ca2+-dependent and -independent mechanisms, resulting in vesicle depletion. Latrophilin-1 is abundant in brain and present in endocrine cells. Latrophilin-3 is also brain-specific, whereas latrophilin-2 expression is ubiquitous.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Adhesion G protein-coupled receptor L2; Calcium-independent alpha-latrotoxin receptor 2; CIRL-2; Cl2aa; latrophilin 2; Latrophilin homolog 1; Latrophilin-2; Lectomedin-1
基因别名: ADGRL2; CIRL2; CL2; KIAA0786; LEC1; LPHH1; LPHN2
UniProt ID: (Human) O95490
Entrez Gene ID: (Human) 23266
分子生物学功能: G-protein coupled receptor