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Invitrogen
LPIN1 Polyclonal Antibody
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FIGURE: 1 / 1
LPIN1 Antibody (PA5-97079) in WB
Western blot analysis of LPIN1 in extracts of rat skeletal muscle. Samples were incubated with LPIN1 Polyclonal antibody (Product # PA5-97079) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-97079
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 261-414 of human Lipin 1 (NP_6637311)
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TERTGQKNPE MLWLWGELPQ AAKSSSPHKM KESSPLSSRK ICDKSHFQAI HSESSDTFSD QSPTLVGGAL LDQNKPQTEM QFVNEEDLET LGAAAPLLPM IEELKPPSAS VVQTANKTDS PSRKRDKRSR HLGADGVYLD DLTDMDPEVA ALYF
Positive Samples: Rat skeletal muscle; Cellular Location: Cytoplasm, Endoplasmic reticulum membrane, Nucleus membrane, cytosol
Target Information
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781P1796; Fatty liver dystrophy protein; KIAA0188; Lipin-1; Phosphatidate phosphatase LPIN1; unnamed protein product
Gene Aliases: 4631420P06; fld; Flde; KIAA0188; Lipin1; LPIN1; mKIAA0188; PAP1
UniProt ID: (Human) Q14693, (Mouse) Q91ZP3
Entrez Gene ID: (Human) 23175, (Rat) 313977, (Mouse) 14245
negative regulation of transcription from RNA polymerase II promoter
mitochondrial fission
lipid metabolic process
triglyceride mobilization
fatty acid catabolic process
dephosphorylation
triglyceride biosynthetic process
positive regulation of histone deacetylation
organ regeneration
ruffle organization
actin cytoskeleton reorganization
cellular response to insulin stimulus
regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
fat cell differentiation
fatty acid metabolic process
mitotic nuclear envelope disassembly
negative regulation of myelination
phosphatidylethanolamine metabolic process
phosphatidic acid metabolic process
positive regulation of cold-induced thermogenesis
negative regulation of phosphatidic acid biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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