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Invitrogen
LPL Polyclonal Antibody
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图: 1 / 4
LPL Antibody (PA5-47033) in ICC/IF
Immunocytochemistry analysis of LPL in immersion fixed SH‚SY5Y human neuroblastoma cell line . Samples were incubated in LPL polyclonal antibody (Product # PA5-47033) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel) and counterstained with DAPI (blue, lower panel). Specific staining was localized to cell surfaces and cytoplasm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-47033
产品规格
种属反应
Human,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human Lipoprotein Lipase/LPL
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects human Lipoprotein Lipase/LPL in direct ELISAs and less than 1% cross-reactivity with recombinant human (rh) LIPG, rhLIPI, and rhPNLIPRP1 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
靶标信息
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha lipase; lipoprotein lipase precursor; LPL; O 1-4-5; phospholipase A1; unnamed protein product
基因别名: HDLCQ11; LIPD
UniProt ID: (Human) P06858, (Mouse) P11152
Entrez Gene ID: (Human) 4023, (Mouse) 16956
lipoprotein lipase activity
phospholipase activity
triglyceride lipase activity
receptor binding
calcium ion binding
protein binding
heparin binding
phosphatidylcholine 1-acylhydrolase activity
lipase activity
apolipoprotein binding
protein homodimerization activity
heparan sulfate proteoglycan binding
protein anchor
carboxylic ester hydrolase activity
lipoprotein particle binding
triglyceride binding
retinoid metabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
triglyceride metabolic process
response to bacterium
positive regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol storage
lipid catabolic process
triglyceride biosynthetic process
triglyceride catabolic process
cellular response to nutrient
positive regulation of chemokine production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
chylomicron remodeling
very-low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
very-low-density lipoprotein particle clearance
cholesterol homeostasis
positive regulation of fat cell differentiation
positive regulation of inflammatory response
low-density lipoprotein particle mediated signaling
triglyceride homeostasis
cellular response to fatty acid
negative regulation of cellular response to insulin stimulus
positive regulation of adipose tissue development
positive regulation of triglyceride transport
positive regulation of chemokine (C-X-C motif) ligand 2 production
phospholipid metabolic process
response to glucose
positive regulation of lipid storage
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