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Invitrogen
LRGUK Polyclonal Antibody
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产品信息
PA5-56175
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SNMGDFLHST DRNYLIKFWA KLSAKKTPAE RDSIHRQHEA ARQALMGRIR PDHTLLFQRG PVPAPLTSGL HYYTTLEELW KSFDLCEDYF KPPFG
Highest antigen sequence identity to the following orthologs: Mouse - 64%, Rat - 61%.
靶标信息
The LRGUK (Leucine-Rich Repeat and Guanylate Kinase-Like Domain Containing 1) gene encodes a protein that plays a critical role in male fertility. It is particularly important for the proper function of the manchette, a microtubule-based structure involved in sperm head shaping and tail formation during spermiogenesis. Research has shown that LRGUK1 is part of a multiprotein complex essential for the initiation of sperm tail growth from the centriole/basal body. Mutations or disruptions in the LRGUK1 gene can lead to defective manchette function, resulting in abnormal sperm morphology and infertility. This gene's role in spermatogenesis underscores its importance in reproductive health, with ongoing studies aimed at elucidating its specific interactions and mechanisms within the manchette complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Leucine-rich repeat and guanylate kinase domain-containing protein; leucine-rich repeats and guanylate kinase domain containing
基因别名: CFAP246; LRGUK
UniProt ID: (Human) Q96M69
Entrez Gene ID: (Human) 136332
