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Invitrogen

LRP1 Recombinant Rabbit Monoclonal Antibody (7D3)

查看其他45个LRP1 (CD91)抗体

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产品信息

MA5-60792

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

7D3

抗原

A synthesized peptide derived from human LRP1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

规格

25 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3701415

靶标信息

CD91 is a 600 kDa type I transmembrane protein composed of an alpha and beta chain. The alpha chain interacts with a variety of structurally and functionally diverse ligands, while the beta chain contains two tyrosine phosphorylation motifs that interact with adaptor and signaling proteins. This receptor is expressed by cells in the monocytic lineage, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblasts. CD91 plays a crucial role in several cellular processes, including ligand endocytosis and trafficking to lysosomes, intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It is involved in cross-presenting antigens via MHC class I molecules on antigen-presenting cells after endocytosis of heat shock protein-peptide complexes. Additionally, CD91 is essential for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of CD91 decreases with age and is found to be lower in brain tissue from Alzheimer patients compared to controls. The receptor also plays a role in cell migration and activating signaling cascades, highlighting its importance in both immune function and disease processes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: A2MR; alpha 2-macroglobulin receptor; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); LRP-1; lrp1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor

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基因别名: A2MR; AI316852; APOER; APR; b2b1554Clo; CD91; DDH3; IGFBP-3R; IGFBP3R; IGFBP3R1; KPA; LRP; LRP1; LRP1A; TGFBR5

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UniProt ID: (Human) Q07954, (Mouse) Q91ZX7, (Rat) G3V928

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Entrez Gene ID: (Human) 4035, (Mouse) 16971, (Rat) 299858

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功能
beta-amyloid binding RNA binding low-density lipoprotein receptor activity scavenger receptor activity calcium ion binding protein binding alpha-2 macroglobulin receptor activity apolipoprotein receptor activity clathrin heavy chain binding apolipoprotein binding signaling receptor activity cargo receptor activity heparan sulfate proteoglycan binding macromolecular complex binding metal ion binding lipoprotein particle receptor binding protease binding protein complex binding poly(A) RNA binding apolipoprotein extracellular matrix structural protein transmembrane signal receptor
参与通路
retinoid metabolic process astrocyte activation involved in immune response lipid metabolic process endocytosis receptor-mediated endocytosis phagocytosis lysosomal transport enzyme linked receptor protein signaling pathway negative regulation of macromolecule metabolic process negative regulation of gene expression regulation of extracellular matrix disassembly positive regulation of cholesterol efflux negative regulation of smooth muscle cell migration regulation of endocytosis negative regulation of Wnt signaling pathway receptor internalization positive regulation of lipid transport regulation of actin cytoskeleton organization aorta morphogenesis lipoprotein transport apoptotic cell clearance transcytosis positive regulation of endocytosis positive regulation of transport regulation of protein metabolic process negative regulation of SMAD protein import into nucleus beta-amyloid clearance amyloid-beta clearance by transcytosis amyloid-beta clearance by cellular catabolic process transport across blood-brain barrier positive regulation of beta-amyloid clearance regulation of extracellular matrix organization positive regulation of reverse cholesterol transport positive regulation of protein localization to plasma membrane positive regulation of transcytosis cellular response to beta-amyloid positive regulation of lysosomal protein catabolic process negative regulation of platelet-derived growth factor receptor-beta signaling pathway protein kinase C-activating G-protein coupled receptor signaling pathway multicellular organism development cholesterol metabolic process cell proliferation negative regulation of neuron projection development regulation of cholesterol transport regulation of phospholipase A2 activity negative regulation of neuron apoptotic process positive regulation of protein transport aging lipoprotein metabolic process
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