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Invitrogen

LRP5 Monoclonal Antibody (2B11)

2 篇参考文献
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产品信息

MA5-17113

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

-
查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

1:200-1:400
-

酶联免疫吸附实验 (ELISA)

1:10,000
-
产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

2B11

抗原

Purified recombinant fragment of human LRP5 expressed in E. Coli.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2538584

产品详细信息

MA5-17113 targets LRP5 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples.

The MA5-17113 immunogen is purified recombinant fragment of human LRP5 expressed in E. Coli.

MA5-17113 detects LRP5 which has a predicted molecular weight of approximately 179kDa.

靶标信息

LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: HGNC:6697; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-7; LRP5

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基因别名: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7; LRP5; LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2

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UniProt ID: (Human) O75197

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Entrez Gene ID: (Human) 4041

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功能
protein binding coreceptor activity Wnt-protein binding toxin transporter activity Wnt-activated receptor activity
参与通路
gastrulation with mouth forming second vasculature development positive regulation of mesenchymal cell proliferation osteoblast development glucose catabolic process amino acid transport endocytosis nervous system development mesodermal cell migration cholesterol metabolic process regulation of blood pressure positive regulation of cell proliferation organ morphogenesis tissue development anterior/posterior pattern specification gene expression Wnt signaling pathway osteoblast proliferation positive regulation of osteoblast proliferation somatic stem cell population maintenance limb morphogenesis extracellular matrix-cell signaling cell migration involved in gastrulation cholesterol homeostasis embryonic digit morphogenesis regulation of apoptotic process response to peptide hormone small molecule metabolic process positive regulation of cell differentiation positive regulation of fat cell differentiation regulation of osteoblast differentiation negative regulation of osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of cell cycle positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter bone remodeling blood vessel morphogenesis bone marrow development anatomical structure regression retina morphogenesis in camera-type eye canonical Wnt signaling pathway bone development bone morphogenesis branching involved in mammary gland duct morphogenesis mammary gland duct morphogenesis adipose tissue development cell-cell signaling involved in mammary gland development establishment of blood-brain barrier regulation of insulin secretion involved in cellular response to glucose stimulus retina vasculature development in camera-type eye retina vasculature morphogenesis in camera-type eye retinal blood vessel morphogenesis regulation of biological quality cell-cell adhesion Norrin signaling pathway apoptotic process involved in patterning of blood vessels establishment of blood-retinal barrier
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