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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Antibody detects endogenous levels of total LRP6.
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: crooked; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6; transmembrane protein; unnamed protein product
基因别名:
ADCAD2; C030016K15Rik; Cd; Gw; LRP6; ska26; ska
UniProt ID: (Human) O75581, (Mouse) O88572
Entrez Gene ID: (Human) 4040, (Rat) 312781, (Mouse) 16974