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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • LRP6 Antibodies

          Invitrogen

          LRP6 Polyclonal Antibody

          1个已发表图片
          1 篇参考文献
          查看其他22个LRP6抗体

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          Cite LRP6 Polyclonal Antibody

          • 抗体检测数据 (1)
          • 已发表图片 (1)
          LRP6 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          LRP6 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          图: 1 / 2

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          LRP6 Antibody (PA5-67902) in WB

          Western Blot analysis of LRP6 was performed using lysates from SH-SY5Y cells. The membrane was probed with LRP6 Polyclonal Antibody (Product # PA5-67902) using a dilution of 1:1,000 (4°C). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          查看产品

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          LRP6 Antibody in Western Blot (WB)
          LRP6 Antibody in Western Blot (WB)
          LRP6 Polyclonal Antibody

          产品信息

          PA5-67902

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:1,000-1:3,000
          查看1篇已发表文章 1篇已发表文章
          产品规格

          种属反应

          Human, Mouse, Rat

          已发表种属

          Mouse

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Synthesized peptide derived from human LRP6.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          纯化类型

          affinity chromatography

          保存液

          PBS, pH 7.4, with 50% glycerol

          内含物

          0.02% sodium azide

          保存条件

          -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2691702

          产品详细信息

          Predicted to react with Mouse and Rat samples.

          靶标信息

          LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          生物信息学

          蛋白别名: crooked; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6

          查看更多 收起

          基因别名: ADCAD2; C030016K15Rik; Cd; Gw; LRP6; ska26; ska; skax26; STHAG7

          查看更多 收起

          UniProt ID: (Human) O75581, (Mouse) O88572

          查看更多 收起

          Entrez Gene ID: (Human) 4040, (Rat) 312781, (Mouse) 16974

          查看更多 收起

          功能
          low-density lipoprotein receptor activity receptor binding frizzled binding protein binding Wnt-protein binding kinase inhibitor activity toxin transporter activity apolipoprotein binding identical protein binding protein homodimerization activity Wnt-activated receptor activity coreceptor activity involved in Wnt signaling pathway coreceptor activity involved in canonical Wnt signaling pathway molecular_function coreceptor activity apolipoprotein
          参与通路
          neural tube closure negative regulation of protein phosphorylation pericardium morphogenesis negative regulation of protein kinase activity positive regulation of cytosolic calcium ion concentration chemical synaptic transmission embryonic pattern specification neural crest formation neural crest cell differentiation Wnt signaling pathway single organismal cell-cell adhesion cerebellum morphogenesis thalamus development cerebral cortex development midbrain-hindbrain boundary development negative regulation of smooth muscle cell apoptotic process external genitalia morphogenesis odontogenesis of dentin-containing tooth response to peptide hormone Wnt signaling pathway involved in dorsal/ventral axis specification canonical Wnt signaling pathway involved in neural crest cell differentiation canonical Wnt signaling pathway involved in regulation of cell proliferation positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity palate development convergent extension embryonic retina morphogenesis in camera-type eye canonical Wnt signaling pathway face morphogenesis trachea cartilage morphogenesis cellular response to cholesterol dopaminergic neuron differentiation negative regulation of protein serine/threonine kinase activity protein localization to plasma membrane primitive streak formation negative regulation of canonical Wnt signaling pathway receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport Wnt signaling pathway involved in somitogenesis axis elongation involved in somitogenesis positive regulation of canonical Wnt signaling pathway toxin transport beta-catenin destruction complex disassembly midbrain dopaminergic neuron differentiation Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification gastrulation with mouth forming second somitogenesis heart looping morphogenesis of an epithelium positive regulation of mesenchymal cell proliferation axis elongation regulation of transcription, DNA-templated dorsal/ventral axis specification anterior/posterior pattern specification cerebral cortex cell migration forebrain radial glial cell differentiation forebrain generation of neurons Wnt signaling pathway involved in forebrain neuroblast division neural tube development formation of radial glial scaffolds negative regulation of Wnt signaling pathway regulation of ossification embryonic limb morphogenesis forebrain development midbrain development limb morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis post-anal tail morphogenesis cell migration involved in gastrulation regulation of cell proliferation embryonic digit morphogenesis positive regulation of apoptotic process regulation of fat cell differentiation negative regulation of fat cell differentiation positive regulation of ossification positive regulation of bone resorption bone remodeling embryonic camera-type eye morphogenesis generation of neurons skeletal system morphogenesis negative regulation of epithelial cell proliferation response to folic acid retina morphogenesis in camera-type eye regulation of cell development bone morphogenesis branching involved in mammary gland duct morphogenesis mammary placode formation mammary gland duct morphogenesis canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation negative regulation of non-canonical Wnt signaling pathway negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis negative regulation of planar cell polarity pathway involved in pericardium morphogenesis negative regulation of planar cell polarity pathway involved in neural tube closure endocytosis receptor-mediated endocytosis multicellular organism development
          It has to be done as per old AB suggested Products section.
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