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Abnova
LRRC23 Polyclonal Antibody, MaxPab™
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产品信息
H00010233-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
LRRC23 (AAH29858, 1 a.a. approximately 343 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.39 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSDEDDLEDS EPDQDDSEKE EDEKETEEGE DYRKEGEEFP EEWLPTPLTE DMMKEGLSLL CKTGNGLAHA YVKLEVKERD LTDIYLLRSY IHLRYVDISE NHLTDLSPLN YLTHLLWLKA DGNLLRSAQM NELPYLQIAS FAYNQITDTE GISHPRLETL NLKGNSIHMV TGLDPEKLIS LHTVELRGNQ LESTLGINLP KLKNLYLAQN MLKKVEGLED LSNLTTLHLR DNQIDTLSGF SREMKSLQYL NLRGNMVANL GELAKLRDLP KLRALVLLDN PCTDETSYRQ EALVQMPYLE RLDKEFYEEE ERAEADVIRQ RLKEEKEQEP EPQRDLEPEQ SLI
靶标信息
The LRRC23 (Leucine-Rich Repeat Containing 23) gene encodes a protein that is an evolutionarily conserved component of the radial spoke complex in sperm flagella. It is located on human chromosome 12. The LRRC23 protein interacts with radial spoke head proteins such as RSPH3A and RSPH3B, crucial for the structural integrity and proper function of the radial spokes, which are essential for flagellar motility. Mutations or deficiencies in LRRC23 have been linked to male infertility, specifically causing asthenozoospermia, characterized by reduced sperm motility. Studies have identified various mutations in LRRC23 that result in disorganized radial spokes and impaired sperm motility, leading to infertility
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Leucine-rich protein B7; Leucine-rich repeat-containing protein 23
基因别名: LRPB7; LRRC23
UniProt ID: (Human) Q53EV4
Entrez Gene ID: (Human) 10233
