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Invitrogen
LRRC4C Monoclonal Antibody (755720)
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LRRC4C Antibody (MA5-24363) in IHC (P)
Immunohistochemical analysis of LRRC4C in immersion fixed paraffin-embedded sections of human spinal cord. Samples were incubated in LRRC4C monoclonal antibody (Product # MA5-24363) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the dorsal horn.
产品信息
MA5-24363
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
755720
抗原
Mouse myeloma cell line NS0-derived recombinant human NGL-1/LRRC4C Gln45-Lys527 (predicted)
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, no cross-reactivity with recombinant human (rh) LRRC4 or rhNGL-3/LRRC4B is observed.
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
靶标信息
Leucine-rich repeat-containing 4C (LRRC4C), also known as Netrin-G ligand 2 (NGL-2), is a gene highlighted for its expression in the nervous system, particularly the brain. It is a member of the leucine-rich repeat superfamily, which plays a significant role in cell adhesion and signaling pathways critical for synaptic connectivity and neuronal development. LRRC4C is involved in neural processes such as axon guidance and synapse formation, aiding in the establishment of functional neural circuits. Additionally, research has suggested that LRRC4C may function as a tumor suppressor, particularly in gliomas, indicating its potential role in neuro-oncological disorders. Variations or deletions in this gene have been linked to neurodevelopmental disorders, demonstrating its importance in normal brain function and development. Furthermore, LRRC4C's expression patterns and associations with cancer also suggest its potential as a prognostic marker in clinical settings.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Leucine-rich repeat-containing protein 4C; Netrin-G1 ligand; NGL-1
基因别名: KIAA1580; LRRC4C; NGL-1; NGL1; UNQ292/PRO331
UniProt ID: (Human) Q9HCJ2
Entrez Gene ID: (Human) 57689
