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Invitrogen
LRRFIP1 Polyclonal Antibody
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LRRFIP1 Antibody (PA5-23445) in WB
Western blot analysis of LRRFIP1 in human heart lysate using 1) pre-bleed and 2) LRRFIP1 antibody, and LRRFIP1 antibody in 3) mouse heart lysate at 3 and 5 µg/mL, respectively.. Samples were incubated in LRRFIP1 polyclonal antibody (Product # PA5-23445) followed by a goat anti-rabbit Ig HRP secondary antibody. PicoTect ECL substrate solution was used for this test.
产品信息
PA5-23445
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acid 200 to 250 of human LRRFIP1.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Leucine-rich repeat FLI-I interacting protein 1 (LRRFIP1/FLAP-1) is a MyD88-interacting signal protein which mediates either induction or repression of TLR signaling. Flap-1 directly interacts with β-catenin and activates β-catenin-dependent transcription activity. Flap-1 or LRRFIP1 was also shown to bind the TNF- -308 promoter polymorphism site, suggesting its possible role in the regulation of TNF- production. FLAP-1 along with LRRFIP2 and FLIIH serve as a balance in coordinating inflammatory response after infection, and may act as a novel target in the control of agonist-induced TLR-mediated inflammatory and autoimmune diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLAP (FLI LRR associated protein); Flap-1; FLI-LRR-associated protein 1; GC-binding factor 2; H186 FLAP; HUFI1; leucine rich repeat (in FLII) interacting protein 1; Leucine-rich repeat flightless-interacting protein 1; LRR FLII-interacting protein 1; NEDD8-conjugating enzyme; TAR RNA-interacting protein
基因别名: AU024550; Flap; FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2; HUFI-1; LRRFIP1; TRIP
UniProt ID: (Human) Q32MZ4, (Mouse) Q3UZ39
Entrez Gene ID: (Human) 9208, (Mouse) 16978
