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Invitrogen
LRRN1 Polyclonal Antibody
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LRRN1 Antibody (PA5-47684) in IHC (F)
Immunohistochemical analysis of LRRN1 in immersion fixed frozen sections of embryonic mouse somites (E9.5). Samples were incubated in LRRN1 polyclonal antibody (Product # PA5-47684) using a dilution of 10 µg/mL overnight at 4 °C followed by NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red) and counterstained with DAPI (blue).
产品信息
PA5-47684
产品规格
种属反应
Human,
Mouse
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant human LRRN1 Ser26-Ala631
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human NLRR-3 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Leucine-rich repeat neuronal 1 (LRRN1) is a gene located on chromosome 3q23, which encodes a transmembrane protein belonging to the leucine-rich repeat (LRR) family. This protein plays a significant role in neural development and synaptic plasticity due to its involvement in cell-cell adhesion and signaling pathways. LRRN1 has been implicated in brain development processes, especially in synapse organization and neuronal differentiation. Its expression is primarily localized to the central nervous system, indicating its importance in neurodevelopmental functions. Research has highlighted LRRN1's potential involvement in cognitive functions, and alterations in its expression have been associated with various neurological disorders. Additionally, LRRN1 is thought to contribute to the establishment of neuronal networks by modulating interactions between neurons through extracellular matrix components. Current studies are exploring its contributions to neuropathological conditions, providing insights into its relevance in brain health and disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: fibronectin type III, immunoglobulin and leucine rich repeat domains 3; Leucine-rich repeat neuronal protein 1; LRN; Neuronal leucine-rich repeat protein 1; NLRR-1
基因别名: 2810047E21Rik; FIGLER3; KIAA1497; LRRN1; Nbla10449; NLRR-1; UNQ693/PRO1338
UniProt ID: (Human) Q6UXK5, (Mouse) Q61809
Entrez Gene ID: (Human) 57633, (Mouse) 16979
