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A suggested positive control is SK-N-SH cell lysate.
PA5-21097 can be used with blocking peptide PEP-1211.
The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Leucine-rich repeat neuronal 2 protein; leucine-rich repeat transmembrane neuronal 2 protein; Leucine-rich repeat transmembrane neuronal protein 2
基因别名: AI851755; BB129880; C630011A14Rik; KIAA0416; LRRN2; LRRTM2; mKIAA0416
UniProt ID: (Human) O43300, (Mouse) Q8BGA3, (Rat) D4A7P2
Entrez Gene ID: (Human) 26045, (Mouse) 107065, (Rat) 685472