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Invitrogen
LSD1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-90711
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.90 mg/mL
规格
90 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: Cellular Location: Nucleus
Immunogen sequence: LSEDEYYSEE ERNAKAEKEK KLPPPPPQAP PEEENESEPE EPSGVEGAAF QSRLPHDRMT SQEAACFPDI ISGPQQTQKV FLFIRNRTLQ LWLDNPKIQL TFEATLQQLE APYNSDTVLV HRVHSYLERH GLINFGIYKR IKPLPTKKTG KVIIIGSGVS GLAAARQLQS FGMDVTLLEA RDRVGGRVAT FRKGNYVADL GAMVVTGLGG NPMAVVSKQV NMELAKIKQK CPLYEANGQA VPKEKDEMVE Q
靶标信息
LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: amine oxidase (flavin containing) domain 2; BRAF35-HDAC complex protein BHC110; F9F13.30; F9F13_30; Flavin-containing amine oxidase domain-containing protein 2; Flavin-containingso amine oxidase domain-containing protein 2; LESION SIMULATING DISEASE; LESION SIMULATING DISEASE 1; lysine (K)-specific demethylase 1; lysine-specific histone demethylase 1; Lysine-specific histone demethylase 1A; neuroprotective protein 3; RP1-184J9.1
基因别名: 1810043O07Rik; AA408884; Aof2; D4Ertd478e; Kdm1; Kdm1a; Kiaa0601; Lsd1; mKIAA0601; RGD1562975
UniProt ID: (Mouse) Q6ZQ88, (Rat) A0A8I6G2K8
Entrez Gene ID: (Mouse) 99982, (Rat) 500569
RNA polymerase II transcription factor binding
p53 binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
N-ethylmaleimide reductase activity
oxidoreductase activity
enzyme binding
ligand-dependent nuclear receptor transcription coactivator activity
demethylase activity
histone demethylase activity
histone demethylase activity (H3-K4 specific)
histone demethylase activity (H3-K9 specific)
histone demethylase activity (H3-dimethyl-K4 specific)
MRF binding
reduced coenzyme F420 dehydrogenase activity
sulfur oxygenase reductase activity
malolactic enzyme activity
NADPH:sulfur oxidoreductase activity
transcription regulatory region DNA binding
flavin adenine dinucleotide binding
androgen receptor binding
epoxyqueuosine reductase activity
oxidase
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein demethylation
multicellular organism development
cell proliferation
regulation of primitive erythrocyte differentiation
positive regulation of neuron projection development
chromatin modification
pituitary gland development
granulocyte differentiation
negative regulation of protein binding
histone H3-K9 demethylation
histone H3-K4 demethylation
positive regulation of chromatin binding
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of erythrocyte differentiation
positive regulation of megakaryocyte differentiation
positive regulation of cell size
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
guanine metabolic process
positive regulation of hormone biosynthetic process
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
muscle cell development
oxidation-reduction process
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of transcription from RNA polymerase II promoter by histone modification
positive regulation of neural precursor cell proliferation
positive regulation of stem cell proliferation
alternative mRNA splicing, via spliceosome
response to organic cyclic compound
cerebral cortex development
neuron maturation
response to fungicide
cellular response to cAMP
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