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Invitrogen
LXR beta Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-20886
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid peptide from near the amino terminus human LXR-B.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human lung tissue lysate.
PA5-20886 can be used with blocking peptide PEP-1000.
Target Information
The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Liver X receptor beta; LXR beta; nuclear orphan receptor LXR-beta; Nuclear receptor subfamily 1 group H member 2; Orphan nuclear receptor OR-1; Oxysterols receptor LXR-beta; Retinoid X receptor-interacting protein No.15; ubiquitous receptor; Ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 2; UR
Gene Aliases: AI194859; LXR; LXRB; LXRbeta; NER1; Nr1h2; OR-1; RIP15; Unr; Unr2; UR
UniProt ID: (Mouse) Q60644, (Rat) Q62755
Entrez Gene ID: (Mouse) 22260, (Rat) 58851
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
apolipoprotein A-I receptor binding
sequence-specific DNA binding
metal ion binding
retinoid X receptor binding
ATPase binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of gene expression
negative regulation of gene expression
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol efflux
positive regulation of lipid storage
negative regulation of cholesterol storage
intracellular receptor signaling pathway
positive regulation of cellular protein metabolic process
negative regulation of lipid transport
positive regulation of cholesterol transport
cholesterol homeostasis
steroid hormone mediated signaling pathway
cellular lipid metabolic process
positive regulation of fatty acid biosynthetic process
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
negative regulation of pinocytosis
positive regulation of lipoprotein lipase activity
lipid homeostasis
positive regulation of high-density lipoprotein particle assembly
positive regulation of pancreatic juice secretion
positive regulation of secretion of lysosomal enzymes
regulation of cholesterol homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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