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Invitrogen
LXR beta Polyclonal Antibody
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LXR beta Antibody (PA5149861) in IHC (P)
Immunohistochemistry analysis of LXR beta in paraffin-embedded Mouse Spinal cord tissue. Samples were incubated with LXR beta Polyclonal (Product # PA5149861) antibody using a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5149861
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant Liver X Receptor Beta (LXRb) (Met1-Glu446)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Liver X receptor beta; LXR beta; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Orphan nuclear receptor OR-1; Oxysterols receptor LXR-beta; Retinoid X receptor-interacting protein No.15; ubiquitous receptor; Ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 2; UR
基因别名: AI194859; LXR; LXRB; LXRbeta; NER; NER1; NR1H2; OR-1; RIP15; UNR; Unr2; UR
UniProt ID: (Mouse) Q60644, (Rat) Q62755
Entrez Gene ID: (Pig) 100525290, (Mouse) 22260, (Rat) 58851
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
apolipoprotein A-I receptor binding
sequence-specific DNA binding
metal ion binding
retinoid X receptor binding
ATPase binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of gene expression
negative regulation of gene expression
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol efflux
positive regulation of lipid storage
negative regulation of cholesterol storage
intracellular receptor signaling pathway
positive regulation of cellular protein metabolic process
negative regulation of lipid transport
positive regulation of cholesterol transport
cholesterol homeostasis
steroid hormone mediated signaling pathway
cellular lipid metabolic process
positive regulation of fatty acid biosynthetic process
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
negative regulation of pinocytosis
positive regulation of lipoprotein lipase activity
lipid homeostasis
positive regulation of high-density lipoprotein particle assembly
positive regulation of pancreatic juice secretion
positive regulation of secretion of lysosomal enzymes
regulation of cholesterol homeostasis
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