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Invitrogen
LYK5 Polyclonal Antibody
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产品信息
PA1-41207
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 300-350 of human STRAD (isoform 1).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The amino acid sequence used is 100% homologous in Yellow Fluorescent Protein (YFP) and Cyan Fluorescent Protein (CFP).
靶标信息
LYK5; STE20-related Adaptor Protein (STRAD); FLJ90524. Gene Map Locus is 17q23.3 and members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: protein kinase LYK5; Serologically defined breast cancer antigen NY-BR-96; STE20-like pseudokinase; STE20-related adapter protein; STE20-related kinase adapter protein alpha; STRAD alpha
基因别名: 2610019A05Rik; 6030402H20Rik; AI480680; E130112C09Rik; LYK5; NY-BR-96; PMSE; Stlk; STRAD; STRADA
UniProt ID: (Human) Q7RTN6, (Mouse) Q3UUJ4
Entrez Gene ID: (Human) 92335, (Mouse) 72149
protein kinase activity
protein binding
ATP binding
kinase binding
protein kinase activator activity
protein serine/threonine kinase activator activity
protein serine/threonine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
protein export from nucleus
cell cycle arrest
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
cell cycle
Rho protein signal transduction
regulation of mitotic cell cycle
cell migration
signal transduction by protein phosphorylation
actin cytoskeleton organization
stress-activated protein kinase signaling cascade
regulation of apoptotic process
regulation of MAPK cascade
protein heterooligomerization
