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Invitrogen
LYPD8 Monoclonal Antibody (961703)
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产品信息
MA5-61988
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
961703
抗原
Human embryonic kidney cell line HEK293-derived transfected with human LYPD8, Met1-Asn215
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
LYPD8 (Ly6/PLAUR domain-containing 8) is a gene that encodes a protein involved in the regulation of the intestinal immune system and maintenance of gut homeostasis. The LYPD8 protein is primarily expressed in the epithelial cells of the colon and plays a crucial role in protecting the intestinal lining from pathogenic bacteria. It achieves this by binding to flagellated bacteria, thereby preventing their motility and subsequent invasion of the gut epithelium. This action helps to maintain a balanced microbial environment and prevents inflammation that can lead to conditions such as colitis. LYPD8 is part of the broader Ly6/uPAR protein family, which is known for its involvement in immune responses and cell signaling. Alterations or deficiencies in LYPD8 expression have been linked to an increased susceptibility to inflammatory bowel diseases (IBD) and other gastrointestinal disorders. Understanding the function and regulatory mechanisms of LYPD8 is essential for developing new therapeutic strategies aimed at enhancing gut barrier function and treating inflammatory conditions of the intestine. Research into LYPD8 also provides valuable insights into host-microbe interactions and the maintenance of mucosal immunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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