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Invitrogen
Lactoferrin Polyclonal Antibody
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产品信息
PA5-111498
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PNHAVVSRMD KVERLKQVLL HQQAKFGRNG SDCPDKFCLF QSETKNLLFN DNTECLARLH GK
Highest antigen sequence indentity to the following orthologs: Mouse - 77%, Rat - 69%.
靶标信息
Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CKRX; epididymis luminal protein 110; Growth-inhibiting protein 12; Kaliocin 1; kaliocin-1; Kaliocin1; lactoferricin; Lactoferricin H; Lactoferrin; lactoferroxin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH; neutrophil lactoferrin; Talalactoferrin
基因别名: GIG12; HEL110; HLF2; LF; LTF
UniProt ID: (Human) P02788
Entrez Gene ID: (Human) 4057
ossification
regulation of cytokine production
retina homeostasis
innate immune response in mucosa
transcription, DNA-templated
proteolysis
ion transport
humoral immune response
antibacterial humoral response
antifungal humoral response
negative regulation of lipopolysaccharide-mediated signaling pathway
regulation of tumor necrosis factor production
negative regulation of ATPase activity
iron assimilation by chelation and transport
positive regulation of osteoblast proliferation
positive regulation of toll-like receptor 4 signaling pathway
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
cellular protein metabolic process
negative regulation by host of viral process
negative regulation of viral genome replication
cell redox homeostasis
positive regulation of osteoblast differentiation
negative regulation of viral process
positive regulation of NF-kappaB transcription factor activity
bone morphogenesis
positive regulation of protein serine/threonine kinase activity
positive regulation of bone mineralization involved in bone maturation
negative regulation of single-species biofilm formation in or on host organism
positive regulation of chondrocyte proliferation
negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
negative regulation of osteoclast development
