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Invitrogen
Lactoferrin Monoclonal Antibody (1A10)
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产品信息
MA5-33350
产品规格
种属反应
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
1A10
抗原
Mouse lactoferrin peptide
偶联物
形式
Liquid
浓度
100 µg/mL
纯化类型
Protein G
保存液
PBS with 0.1% BSA
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Product is supplied at 1 mL (100 µL/mL).
Application Notes: Flow cytometry - For intracellular staining 293 cells were permeabilized and stained with 2 µg/mL Lactoferrin Monoclonal Antibody (1A10).
靶标信息
Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
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生物信息学
蛋白别名: CKRX; Kaliocin 1; Kaliocin1; Lactoferricin H; Lactoferrin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH; minisatellite 10r detected by probe MMS10; N lobe
基因别名: Csp82; Lf; Ltf; MMS10R; Ms10r
UniProt ID: (Mouse) P08071
Entrez Gene ID: (Mouse) 17002
ossification
regulation of cytokine production
innate immune response in mucosa
immune system process
proteolysis
transport
ion transport
antibacterial humoral response
antifungal humoral response
negative regulation of lipopolysaccharide-mediated signaling pathway
regulation of tumor necrosis factor production
negative regulation of ATPase activity
positive regulation of osteoblast proliferation
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation by host of viral process
negative regulation of viral genome replication
positive regulation of osteoblast differentiation
negative regulation of viral process
positive regulation of NF-kappaB transcription factor activity
iron ion homeostasis
bone morphogenesis
positive regulation of protein serine/threonine kinase activity
negative regulation of single-species biofilm formation in or on host organism
positive regulation of chondrocyte proliferation
