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Invitrogen
Lamin B2 Monoclonal Antibody (LN43)
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产品信息
MA1-06104
应用
建议稀释比
已发表文章
产品规格
种属反应
Hamster,
Human,
Mouse,
Pig,
Xenopus,
Zebrafish
已发表种属
C. elegans,
Hamster,
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
LN43
抗原
Detergent insoluble fraction of potoroo cell line PtK1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
purified
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-06104 detects lamin B2 in human, mouse, porcine, Xenopus laevis, zebrafish and hamster samples.
MA1-06104 has sucessfully been used in FACS, immunohistochemistry, and Western blotting procedures.
The MA1-06104 immunogen is a detergent insoluble fraction of potoroo cell line PtK1.
Store at 4°C, or in small aliquots at -20°C.
靶标信息
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: lamin B2; lamin B3; Lamin-B2; MGC2721
基因别名: EPM9; fc15d06; im:7142331; LAMB2; lamin; Lamin-B2; Lamin-L(II); LMN2; LMNB2; lmnb2-a; lmnb2-b; wu:fb94e05; wu:fb95e12; wu:fc15d06; wu:fc49h03; XELAEV_18009631mg
UniProt ID: (Human) Q03252, (Mouse) P21619
Entrez Gene ID: (Pig) 100620983, (Human) 84823, (Mouse) 16907, (Chinese hamster) 100766421, (Zebrafish) 30196, (Xenopus) 394291
