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Rockland
Laminin Polyclonal Antibody
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FIGURE: 1 / 2
Laminin Antibody (600-401-116-05) in IHC (P)
Immunohistochemistry of rabbit anti-Laminin antibody (Product # 600-401-116-0.1). Tissue: human placenta. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: Anti-Laminin at 5 µg/mL for 1 h at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Staining: Laminin as precipitated red signal with hematoxylin purple nuclear counte... View More
Product Details
600-401-116-05
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-Laminin Antibody was produced by repeated immunizations with a mixture of synthetic peptides corresponding to regions of adherence on laminin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
0.125M sodium borate, pH 8, with 0.005M EDTA, 0.075M NaCl
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at 4°C prior to opening.
This product is stable 4°C as an undiluted liquid (dilute only prior to immediate use).
For extended storage mix with an equal volume of glycerol, aliquot contents and freeze at -20degC or below.
Target Information
Laminin is a crucial glycoprotein that plays a significant role in the extracellular matrix, particularly within the basement membrane. It is composed of three subunits: alpha, beta, and gamma chains. These chains are disulfide-linked polypeptides that together form a heterotrimer, resembling the shape of a cross. The human genome encodes 11 genetically distinct laminin chains, which combine to form over 14 different laminin isoforms, each with specific tissue distributions and functions. Laminins can bind to other laminin molecules, as well as integrins and other matrix proteins, providing structural support and influencing cell differentiation, migration, and adhesion. These glycoproteins are vital during early embryonic development, where they contribute to the formation of basement membrane-like structures, even in the absence of type IV collagen. The evolutionary origin of laminin gene families can be traced back to early branching animals, providing insights into metazoan gene family development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Laminin A chain; Laminin B1 chain; Laminin B2 chain; Laminin M chain; Laminin subunit alpha-1; Laminin subunit alpha-2; Laminin subunit beta-1; Laminin subunit gamma-1; laminin, alpha 1; laminin, alpha 2; laminin, beta 1; laminin, gamma 1 (formerly LAMB2); Laminin-1 subunit alpha; Laminin-1 subunit beta; Laminin-1 subunit gamma; Laminin-10 subunit beta; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-12 subunit alpha; Laminin-12 subunit beta; Laminin-2 subunit alpha; Laminin-2 subunit beta; Laminin-2 subunit gamma; Laminin-3 subunit alpha; Laminin-3 subunit gamma; Laminin-4 subunit alpha; Laminin-4 subunit gamma; Laminin-6 subunit beta; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit beta; Laminin-8 subunit gamma; Laminin-9 subunit gamma; Merosin heavy chain; S-LAM alpha; S-LAM gamma; S-laminin subunit alpha; S-laminin subunit gamma
Gene Aliases: CLM; LAMA; LAMA1; LAMA2; LAMB1; LAMB2; LAMC1; LAMM; LIS5; PTBHS; S-LAM-alpha
UniProt ID: (Human) P25391, (Human) P24043, (Human) P07942, (Human) P11047
Entrez Gene ID: (Human) 284217, (Human) 3908, (Human) 3912, (Human) 3915
cell adhesion
cell surface receptor signaling pathway
regulation of cell adhesion
extracellular matrix organization
regulation of cell migration
regulation of embryonic development
axon guidance
muscle organ development
myelination in peripheral nervous system
positive regulation of synaptic transmission, cholinergic
neuronal-glial interaction involved in cerebral cortex radial glia guided migration
positive regulation of cell migration
neuron projection development
substrate adhesion-dependent cell spreading
endodermal cell differentiation
odontogenesis
positive regulation of epithelial cell proliferation
protein complex assembly
endoderm development
cell migration
extracellular matrix disassembly
hemidesmosome assembly
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