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Invitrogen
Lassa virus RING finger protein Z Polyclonal Antibody
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Lassa virus RING finger protein Z Antibody (PA5-112046) in WB
Western Blot analysis of Lassa virus RING finger protein Z in non-transfected (–) and transfected (+) 293T whole cell extract. Sample was separated with 15% SDS-PAGE, incubated with polyclonal antibody (Product # PA5-112046) at a dilution of 1:5,000, and followed by HRP-conjugated anti-rabbit IgG.
产品信息
PA5-112046
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of Lassa virus RING finger protein Z (Lassa virus (strain mouse/Sierra Leone/Josiah/1976)). The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.11 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. Also selectively represses protein production by associating with host eIF4E.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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