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Invitrogen
Lin28A/B Recombinant Rabbit Monoclonal Antibody (K01_4T31)
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产品信息
MA567765
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_4T31
抗原
A synthesized peptide derived from human LIN28.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 50% glycerol, 150mM NaCl, 0.05% BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CSD-containing, CCHC zinc finger motif containing; Lin-28.2; Lin-28A; Lin-28B; Protein lin-28 homolog A; Protein lin-28 homolog B; RNA-binding protein LIN-28; unnamed protein product; Zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
基因别名: CSDD1; CSDD2; LIN-28; lin-28A; LIN28; LIN28A; LIN28B; ZCCHC1
UniProt ID: (Human) Q9H9Z2, (Human) Q6ZN17
Entrez Gene ID: (Human) 79727, (Human) 389421
germ cell development
miRNA metabolic process
miRNA catabolic process
posttranscriptional regulation of gene expression
negative regulation of translation
stem cell population maintenance
gene silencing by RNA
pre-miRNA processing
RNA 3'-end processing
positive regulation of TOR signaling
positive regulation of neuron differentiation
negative regulation of glial cell differentiation
positive regulation of translation
stem cell differentiation
positive regulation of protein kinase B signaling
regulation of gene silencing by miRNA
cellular response to glucose stimulus
positive regulation of cell proliferation involved in kidney development
negative regulation of pre-miRNA processing
positive regulation of cytoplasmic translation
RNA destabilization
positive regulation of miRNA catabolic process
negative regulation of primary miRNA processing
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