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Invitrogen
NGFR Monoclonal Antibody (ME20.4)
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FIGURE: 1 / 1
NGFR Antibody (MA1-18418) in ICC/IF
Nature 2018 -
Extended Data Figure 4: Validation of novel lineages in mouse and human by immunofluorescence. a , Immunofluorescence in mouse tracheal epithelium for Krt4 (green, arrowheads), Krt5 (basal), Krt8 (luminal), Scgb1a1 (club, secretory) and Foxj1 (ciliated) (n=3 animals). b , Immunofluorescence in differentiated HBEC cultures for FOXN4 (red, arrows), FOXJ1 (arrowheads mark FOXJ1 low cells) and Acetylated alpha... View More
Product Details
MA1-18418
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Cat,
Human,
Sheep,
Pig,
Rabbit
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
ME20.4
Immunogen
Human WM245 melanoma cells.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with the addition of 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD271; CD271 antigen; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); NGF receptor; p-75; p75 ICD; p75 ntr; TNFR superfamily, member 16; TNR16; Tumor necrosis factor receptor superfamily member 16; unnamed protein product
Gene Aliases: CD271; Gp80-LNGFR; NGFR; NGR; p75(NTR); p75NTR; TNFRSF16
UniProt ID: (Human) P08138
Entrez Gene ID: (Pig) 100525607, (Human) 4804, (Sheep) 101119064, (Dog) 491071, (Rabbit) 100349095
beta-amyloid binding
transmembrane signaling receptor activity
death receptor activity
protein binding
calmodulin binding
coreceptor activity
small GTPase binding
ubiquitin protein ligase binding
signaling receptor activity
neurotrophin binding
nerve growth factor binding
transmembrane signal receptor
cellular glucose homeostasis
hair follicle development
intracellular protein transport
apoptotic process
signal transduction
Rho protein signal transduction
nervous system development
axon guidance
central nervous system development
circadian rhythm
fibroblast growth factor receptor signaling pathway
regulation of gene expression
detection of temperature stimulus
nerve development
cell differentiation
negative regulation of cell migration
hair follicle morphogenesis
circadian regulation of gene expression
dorsal aorta development
negative regulation of fibroblast growth factor receptor signaling pathway
regulation of cell proliferation
odontogenesis of dentin-containing tooth
positive regulation of odontogenesis of dentin-containing tooth
glucose homeostasis
positive regulation of apoptotic process
skin development
fibroblast proliferation
positive regulation of fibroblast proliferation
rhythmic process
neuron apoptotic process
negative regulation of hair follicle development
extrinsic apoptotic signaling pathway
presynaptic modulation of chemical synaptic transmission
positive regulation of protein localization to nucleus
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
cellular response to beta-amyloid
positive regulation of endothelial cell apoptotic process
positive regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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