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Invitrogen
HLA-DR/DP/DQ Monoclonal Antibody (WR18)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA1-80678
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
WR18
抗原
Human HLA Class II (DP, DQ, DR).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
200 µg
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. A suggested positive control for immunohistochemical applications is tonsil. Removal of sodium azide by dialysis is recommended prior to use in functional assays. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Mouse anti Human HLA DP DQ DR antibody, clone WR18 reacts with a monomorphic determinant common to DP, DQ and DR beta chains, which are expressed by antigen presenting cells, B cells, monocytes and activated T lymphocytes.
靶标信息
MHC class II molecules are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DR beta-5; DR2-beta-2; Dw2; FLJ75017; FLJ76359; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA class II histocompatibility antigen, DR alpha chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA-D; HLA-DQ; HLA-DR; HLA-DRB1; Human leukocyte antigen DRB1; MHC Class 2; MHC class II; MHC class II antigen DPB1; MHC class II antigen DQB1; MHC class II antigen DRA; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC HLA-D; MHC II HLA; XXbac-BPG161M6.1
基因别名: HLA-DP1B; HLA-DPB1; HLA-DQB; HLA-DQB1; HLA-DRA; HLA-DRA1; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5
Entrez Gene ID: (Human) 3115, (Human) 3119, (Human) 3122, (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127
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