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Invitrogen
Collagen II Monoclonal Antibody (2B1.5), Biotin
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FIGURE: 1 / 1
Collagen II Antibody (MA5-12786) in ICC/IF
Nature 2012 -
Figure 2 Reprogramming non-cardiomyocytes toward a cardiac fate in vivo by GHMT a. Heart sections of Fsp1-cre/Rosa26-LacZ mice uninjured or three weeks post-MI followed by injection of GFP or GHMT retroviruses. GFP-infected myocardium showed only beta-gal + non-cardiomyocytes, GHMT-infected myocardium showed extensive beta-gal + non-cardiomyocytes and cardiomyocytes. Black boxes in top panels are enlarged i... View More
Product Details
MA5-12786
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Chicken,
Human,
Mouse,
Rat
Published species
Bovine,
Goat,
Guinea pig,
Human,
Mouse,
Pig,
Rabbit,
Rat,
Sheep
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2B1.5
Immunogen
A purified preparation of lathyritic type II collagen from embryonic chicken sternum
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-12786 targets Collagen II in FACS, IF, IHC (P), and WB applications and shows reactivity with Bovine, Chicken, Human, mouse, and Rat samples.
The MA5-12786 immunogen is a purified preparation of lathyritic type II collagen from embryonic chicken sternum.
Target Information
COL2A1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha 1 type II procollagen; alpha 1 type IIA collagen; alpha collagen type II; Alpha-1 type II collagen; arthroophthalmopathy, progressive (Stickler syndrome); cartilage collagen; CGA; chondrocalcin; Collagen 2; Collagen alpha-1(II) chain; collagen II, alpha-1 polypeptide; collagen type II (Col2A1) gene, enhancer region; collagen, type II, alpha 1; collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital); disproportionate micromelia; MGC131516; pro-alpha 1(II); procollagen alpha 1(II); Procollagen II alpha 1; procollagen, type II, alpha 1; type II collagen; unnamed protein product
Gene Aliases: ANFH; AOM; CB11; CG2A1A; COL11A3; Col2; Col2a; Col2a-1; COL2A1; COLLII; Del1; Dmm; Lpk; M100856; Rgsc856; SEDC; STL1
UniProt ID: (Human) P02458, (Bovine) P02459, (Rat) P05539, (Mouse) P28481
Entrez Gene ID: (Human) 1280, (Chicken) 395069, (Bovine) 407142, (Rat) 25412, (Mouse) 12824
extracellular matrix structural constituent conferring tensile strength
identical protein binding
metal ion binding
platelet-derived growth factor binding
extracellular matrix structural constituent
protein binding
MHC class II protein binding
proteoglycan binding
extracellular matrix structural protein
skeletal system development
cartilage condensation
tissue homeostasis
endochondral ossification
chondrocyte differentiation
heart morphogenesis
proteoglycan metabolic process
central nervous system development
visual perception
sensory perception of sound
regulation of gene expression
extracellular matrix organization
collagen fibril organization
collagen catabolic process
notochord development
inner ear morphogenesis
regulation of immune response
cartilage development
palate development
limb bud formation
embryonic skeletal joint morphogenesis
cartilage development involved in endochondral bone morphogenesis
otic vesicle development
cellular response to BMP stimulus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
anterior head development
growth plate cartilage development
response to mechanical stimulus
response to X-ray
limb morphogenesis
skeletal system morphogenesis
inner ear development
bone development
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to vitamin E
cellular response to nicotine
cellular response to tumor necrosis factor
cellular response to parathyroid hormone stimulus
cellular response to peptide hormone stimulus
response to fibroblast growth factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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