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Invitrogen
CaV3.1 Monoclonal Antibody (N178A/9)
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FIGURE: 1 / 2
CaV3.1 Antibody (MA5-27655) in ICC/IF
Immunofluorescent analysis of CaV3.1 in human neuroblastoma cell line (SK-N-BE). Sample was fixed with 4% formaldehyde (15 min at RT), incubated with CaV3.1 monoclonal antibody (Product # MA5-27655) using a dilution of 1:100 (1 hour at RT), and followed by Goat Anti-Mouse 488, Phalloidin Texas Red and DAPI secondary antibody at a dilution of 1:200, 1:1000 (60 min at RT) and 1:5000 (5 min at RT). Images are shown as follows: (A) DAPI (blue) nuclear stain, B) Phalloidin Texas Red F-Actin stain, C) Cav3,1 Antibody, D) Merged image. Magnificat... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-27655
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N178A/9
Immunogen
Fusion protein amino acids 2052-2172 (cytoplasmic C-terminus) of mouse Cav3.1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
1 µg/mL of MA5-27655 was sufficient for detection of Cav3.1 in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately <200kDa. Does not cross-react with Cav3.2.
This antibody was formerly sold as clone S178A-9.
Target Information
Voltage-dependent Ca2+ channels mediate Ca2+ entry into excitable cells in response to membrane depolarization, and they are involved in a variety of Ca2+-dependent processes, including muscle contraction, hormone or neurotransmitter release and gene expression. Calcium channels are highly diverse, multimeric complexes composed of an alpha-1 subunit, an intracellular beta subunit, a disulfide linked alpha-2/delta subunit and a transmembrane gamma subunit. Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R- types. T-type Ca2+ currents are activated and inactivated more rapidly and at more negative membrane potentials than other Ca2+ current types. T-type Ca2+ channels enhance odor sensitivity by lowering the threshold of spike generation in olfactory receptor cells (ORCs).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CaV T1; Cav3 1; cav3 1c; Cav3.1c; MGC117234; NBR13; Voltage-dependent T-type calcium channel subunit alpha-1G; Voltage-gated calcium channel subunit alpha Cav3.1
Gene Aliases: [a]1G; a1G; alpha-1G; CACNA1G; Cav3.1d; KIAA1123; mKIAA1123
Entrez Gene ID: (Rat) 29717, (Mouse) 12291
action potential
regulation of heart rate
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
response to nickel cation
artery smooth muscle contraction
regulation of ion transmembrane transport
regulation of membrane potential
positive regulation of calcium ion-dependent exocytosis
regulation of calcium ion transport
regulation of atrial cardiac muscle cell membrane depolarization
calcium ion transport into cytosol
calcium ion import
calcium ion transmembrane transport
cellular response to dexamethasone stimulus
membrane depolarization during action potential
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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