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Invitrogen

TREM2 Monoclonal Antibody (78.18)

View all (32) TREM2 antibodies

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Product Details

MA5-28224

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

1:25-1:200
-

Functional Assay (Functional)

Assay-dependent
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG1

Class

Monoclonal

Type

Antibody

Clone

78.18

Immunogen

Mouse TREM-2 Fc fusion protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

500 µg

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745194

Product Specific Information

Rat anti Mouse TREM-2 antibody, clone 78.18 recognizes triggering receptor expressed on myeloid cells 2 (TREM-2), an activating receptor of the Ig superfamily.

Target Information

TREM2 is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: OTTHUMP00000039771; soluble TREM 2; soluble TREM2; sTREM 2; sTREM2; TREM; TREM-2; triggering receptor expressed by myeloid cells-2a; triggering receptor expressed by myeloid cells-2b; triggering receptor expressed on monocytes 2; Triggering receptor expressed on myeloid cells; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2b; triggering receptor expressed on myeloid cells 2c; unnamed protein product

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Gene Aliases: TREM-2; Trem2a; Trem2b; Trem2c

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UniProt ID: (Mouse) Q99NH8

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Entrez Gene ID: (Mouse) 83433

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Function(s)
lipopolysaccharide binding beta-amyloid binding phosphatidylserine binding transmembrane signaling receptor activity protein binding phospholipid binding beta-catenin binding high-density lipoprotein particle binding lipid binding phosphatidylethanolamine binding semaphorin receptor activity kinase activator activity low-density lipoprotein particle binding semaphorin receptor binding apolipoprotein binding apolipoprotein A-I binding very-low-density lipoprotein particle binding signaling receptor activity peptidoglycan binding macromolecular complex binding lipoteichoic acid binding lipoprotein particle binding scaffold protein binding carbohydrate derivative binding sulfatide binding protein tyrosine kinase binding
Process(es)
microglial cell activation microglial cell activation involved in immune response T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of antigen processing and presentation of peptide antigen via MHC class II negative regulation of inflammatory response to antigenic stimulus response to ischemia phagocytosis phagocytosis, recognition phagocytosis, engulfment immune response signal transduction cell surface receptor signaling pathway memory regulation of gene expression negative regulation of autophagy positive regulation of gene expression positive regulation of cholesterol efflux negative regulation of cholesterol storage negative regulation of sequestering of triglyceride positive regulation of high-density lipoprotein particle clearance regulation of lipid metabolic process osteoclast differentiation lipopolysaccharide-mediated signaling pathway regulation of TOR signaling positive regulation of TOR signaling detection of lipopolysaccharide detection of peptidoglycan regulation of interleukin-6 production negative regulation of interleukin-1 beta production negative regulation of tumor necrosis factor production positive regulation of interleukin-10 production negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 4 signaling pathway regulation of toll-like receptor 6 signaling pathway positive regulation of macrophage fusion negative regulation of glial cell apoptotic process social behavior CXCL12-activated CXCR4 signaling pathway defense response to bacterium negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of potassium ion transport apoptotic cell clearance innate immune response regulation of innate immune response positive regulation of osteoclast differentiation respiratory burst after phagocytosis positive regulation of complement activation, classical pathway astrocyte activation cell development response to axon injury positive regulation of protein secretion positive regulation of phagocytosis defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling negative regulation of cell activation positive regulation of chemotaxis positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling lipid homeostasis regulation of resting membrane potential positive regulation of phagocytosis, engulfment microglial cell proliferation negative regulation of astrocyte activation pyroptosis negative regulation of fat cell proliferation positive regulation of ERK1 and ERK2 cascade detection of lipoteichoic acid cellular response to lipoteichoic acid cellular response to peptidoglycan cellular response to glucose stimulus cellular response to lipid cellular response to lipoprotein particle stimulus cellular response to hypoxia semaphorin-plexin signaling pathway regulation of macrophage inflammatory protein 1 alpha production dendritic cell differentiation dendritic spine maintenance beta-amyloid clearance import into cell regulation of hippocampal neuron apoptotic process regulation of plasma membrane bounded cell projection organization cellular response to oxidised low-density lipoprotein particle stimulus complement-mediated synapse pruning neuroinflammatory response positive regulation of neuroinflammatory response negative regulation of neuroinflammatory response amyloid-beta clearance by cellular catabolic process regulation of cytokine production involved in inflammatory response negative regulation of cytokine production involved in inflammatory response positive regulation of beta-amyloid clearance negative regulation of NLRP3 inflammasome complex assembly positive regulation of engulfment of apoptotic cell positive regulation of NIK/NF-kappaB signaling positive regulation of proteasomal protein catabolic process negative regulation of macrophage colony-stimulating factor signaling pathway positive regulation of intracellular signal transduction positive regulation of protein localization to plasma membrane positive regulation of C-C chemokine receptor CCR7 signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of p38MAPK cascade positive regulation of microglial cell activation negative regulation of autophagic cell death positive regulation of microglial cell migration cellular response to beta-amyloid positive regulation of establishment of protein localization positive regulation of CAMKK-AMPK signaling cascade positive regulation of low-density lipoprotein particle clearance excitatory synapse pruning positive regulation of synapse pruning negative regulation of amyloid fibril formation positive regulation of CD40 signaling pathway positive regulation of ATP biosynthetic process
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