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Invitrogen
CD276 (B7-H3) Monoclonal Antibody (MJ18)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-28240
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
MJ18
抗原
Mouse IgG2a Fc-CD276 (aa 1-242)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
250 µg
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes mouse CD276, otherwise known as B7-H3, a ubiquitously expressed transmembrane glycoprotein and member of the B7 family of co-stimulatory molecules, which acts as both a positive and negative regulator of T-cell-mediated immune responses. CD276 is highly expressed in bone during embryogenesis, and can be induced on dendritic cells and monocytes by inflammatory cytokines.
靶标信息
CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B7 homolog 3; costimulatory molecule; Ig protein; sB7 H3; sB7H3; sCD276; soluble B7 H3; soluble B7H3; soluble CD276; unnamed protein product
基因别名: 6030411F23Rik; B7-H3; B7h3; B7RP-2
UniProt ID: (Mouse) Q8VE98
Entrez Gene ID: (Mouse) 102657
regulation of cytokine production
positive regulation of cytokine production
positive regulation of bone mineralization
regulation of interferon-gamma production
negative regulation of interferon-gamma production
negative regulation of interleukin-2 production
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of T cell proliferation
T cell activation
negative regulation of T cell proliferation
positive regulation of osteoblast differentiation
negative regulation of inflammatory response
regulation of immune response
T cell receptor signaling pathway
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
