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Invitrogen
Drebrin Monoclonal Antibody (DBN-N-03)
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FIGURE: 1 / 5
Drebrin Antibody (MA5-28543) in ICC/IF
Immunofluorescence analysis of Drebrin was performed using 70% confluent log phase HEK-293 cells. The cells were fixed with 4% Paraformaldehyde for 10 Minutes, permeabilized with 0.1% Triton™ X-100 for 10 Minutes, and blocked with 2% BSA for 10 Minutes at room temperature. The cells were labeled with Drebrin Monoclonal Antibody (DBN-N-03) (Product # MA5-28543) at 5 µg/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Mouse IgG (H+L), Superclonal™ Recombinant Secondary Antibody, Alexa Fluor 488(Product ... View More
Product Details
MA5-28543
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
DBN-N-03
Immunogen
human drebrin (aa 1-326, N terminal)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 8
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes drebrin, an approximately 100-125 kDa intracellular regulator of actin cytoskeleton.
It has also been successfully used in Mass Cytometry (CyTof).
Target Information
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Developmentally-regulated brain protein; DKFZp434D064; Drebrin; drebrin A; drebrin E; drebrin E2; drebrin-1
Gene Aliases: D0S117E; DBN1; Drba
UniProt ID: (Human) Q16643, (Rat) Q07266, (Mouse) Q9QXS6
Entrez Gene ID: (Human) 1627, (Rat) 81653, (Mouse) 56320
actin filament organization
cell communication by chemical coupling
cell communication by electrical coupling
maintenance of protein location in cell
regulation of neuronal synaptic plasticity
regulation of dendrite development
neural precursor cell proliferation
cell-cell adhesion
nervous system development
generation of neurons
multicellular organism development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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